Objective:To establish aspirin resistance(AR) model in hamster and evaluation.Methods:130 male hamsters,were selected and divided into model group(120) and control group(10).High fat,sugar and salt were fed for 12 weeks,meanwhile oral administration of 0.74 g/kg/d aspirin +2.22 g/kg/d ibuprofen and smoking were given for 4 weeks to build the Aspirin resistance(AR) model.Platelet aggregation(PAG) test was used as the criteria of AR:if adenosine diphosphate(ADP) induced average PAG rate≥70%,and arachidonic acid(AA) induced average PAG rate≥20%,it was AR;if only one item met the criterion,it was aspirin semi resistance (ASR).Results:The PAG was significantly increased(P<0.01) in muliti-factor model,AR and ASR hamster.AR model built in 6 animals,the rate was 5%;ASR model built in 28,the rate was 23%.Conclusion:The pathological environment simulation,combined with the effect of multiple risk factors,experimental AR models are successfully established in hamsters.