Objective: To investigate the role of LIFR in proliferation and involution of infantile hemangiomas.Methods: 52 samples of infantile hemangiomas(30 samples in proliferating phase,22 samples in involution phase classified according criterion of Takahashi),16 samples of vascular malformation and 15 samples of normal skin were obtained from patients underwent surgery from 2009 to 2010.The expressions of LIFR CD133 and Ki67 were examined with SP method of immunohistochemieal technique.The data were dealt with soft SPSS17.0,and less than 0.05 was considered significant.Results: In proliferating phase,a number of vascular endothelial cells highly expressed LIFR、CD133 and Ki67.It was significantly higher than in involution phase,vascular malformation,and normal skin.The difference between proliferating hemangioma and involuting hemangioma was significant(P<0.05).But no significant difference between involuting hemangioma,vascular malformation and normal skin(P>0.05).By spearman’s rank correlation,there were positive correlation relationships among the expressions of LIFR、CD133 and Ki67 in infantile hemangiomas.Conclusions:①Overexpression of LIFR in proliferating hemangioma may correlate with the development of hemangioma.②The cell with high expression of CD133 may play a very important role in the proliferation of infantile hemangiomas.③The expression of LIFR has a positive correlation with CD133 and Ki67 in hemangioma.It may be concluded that LIFR can intensify the expression of CD133 and Ki67 in proliferating hemangioma.