摘要:为治疗少、弱、畸精子症引致的男性不育,用不连续密度梯度离心技术,从质量较差的精液中将活力好的成熟精子分离出来,用于配偶间人工授精(AIH)并已在临床应用中获得成功.处理后的精液中大部分未成熟生殖细胞和其它细胞成分停留于50～60%等渗Percoll界面,90%等渗Percoll层中回收的精子中几乎不含有其它细胞成

摘要:本文报道4个村改良炉灶前后的对比调查,改炉灶后室内空气氟浓度、食品含氟量显著下降,并改善了农村卫生条件,节省大量能源,减轻农户经济负担,其社会效益、经济效益显著.农户对改良炉灶客观评价良好.证实在病区推广实施改良炉灶防制氟病的措施是切实可行和行之有效的.

摘要:作者观察12倒胆石症患者手术中,应用电针刺激耳廓胆胰穴前后,患者奥狄氏括约肌的电活动变化.结果显示:针刺奥狄氏括约肌放电频率由正常对照组的3.27土1.88SB/min下降到0.85±0.79SB/min(P<0.01).提示针刺可以引起奥狄氏括约肌松驰,胆管内压下降,有助于胆汁或胆石的排出并缓解患者的临床症状.这可能是针刺排石的机理之一.

摘要:本文报告了我科自1988年2月至1989年3月收治淋病患者45例,分别用氟哌酸和青霉素进行对照治疗观察.第一组12例,用青霉素160万u/d分二次肌注.第二组20例,用氟哌酸1200mg/d,每次口服600mg,间隔4小时.第三组13例,用青霉素160万u/d加氟哌酸1200mg/d,其用法同上.全部患者均用1/15000高锰酸钾溶液浸洗患部每天2次.,

摘要:Voltage-dependent and Ca~(2+)-activated K~+ channels of the primary cultured coronary artery smooth muscle cells from porcine heart were investigated using the patch-clamp technique. The results are summarized as follows:1). In the inside-out configuration, under quasi-physiological cation gradients conditions(normal Tyrode's solution outside. K~+-rich inside), at a membrane potential of-90mV no discernible channel currents were recorded. Depolarizing the membrane patch revealed a outward single-channel current, and the pattern of the channel activity appeared to be relative to changes in the voltage applied to the membrane. When membrane potentials became more positive, the rectangular-shaped currents with a large amplitude

摘要:The monophasic action potentials(MAP)and transmembrane action potentials(TAP)were simultaneously recorded from rabbit's left ventricular epicardium in situ using a contact electrode and compared with those recorded with an intracellular floating microelectrode. It was found that MAP had a repolarization time course similar to that of the TAP of the adjacent cells and that the changes of MAP and TAP were identical in the amplitude, duration, and configuration in the cases of arrhythmia and administration of tetrodotoxin.Simultaneonsly recorded TAP and MAP showed that their depolarization phase indicated the exact time when the excitation wave arrived at the cell.

摘要:One hundred and sixty-six patients with 180 ureters suffering from symptomatic ureteral stones were treated with extracor poreal shock wave lithotripsy(ESWL)in situ from The mean age of the 108 men and 58 women was 39.9 years(range 20～77).Stone size varied between 6mm and 25mm in maximal dimension. Of the stones 88% were less than 20mm. There were 83(46%)upper, 16(9%)mid and 81(45%) lower ureteral stones. All patients were treated first by in situ ESWL without anesthesia. Of the treatments 78.8% were provided on an outpatient basis. All stones were treaed on a Meizhi JT-3 Lithotripter(home made), receiving a mean of 2022 shock waves at a mean voltage of 11.3KV per treatment. The number of treatments required per stone was directly related to the stone size. Mean numbet of ESWL sessions was 1.

摘要:Two hundred and forty four Wistar rats were used to study the Kupffer Cell(KC)phagocytic function during acute obstructive cholangitis(AOC). The animals were sacrificed respectively at 6, 12, 24, and 48h after operation. KC phagocytic function of colloidal carbon uptake, plasma endotoxin and fibronectin(Fn) were determined, morphology of KC was observed. The results showed that KC phagocytic function and plasma Fn in Group AOC were significantly elevated at 6h and markedly reduced at 48h after operation when compared with the control groups(p<0.05).KC hypertrophy at 6h and KC hypotrophy at 48h were observed. These data indicated that KC phagocytic function varied in different stages during AOC, from hyperfunction in the early stage to hypofunction in advanced stage.

摘要:In order to gain an insight into the electrophysiologic properties of occlusion and reperfusion arrhythmias, a contact electrode was employed to record the monophasic action potential(MAP)on the epicardium in occlusion group and reperfusion group of rabbits 30 minutes after coronary artery occlusion, with electrocardiogram recorded simultaneously, and real-time analysed with a microcomputer.The results showed that in reperfusion group the generation of arrhythmias is earlier, rate of arrhythmias is higher,and the type is singler than in occlusion group. Both MAPA and Vmax were decreased after coronary occlusion, followed by elevation of the plateau phase, MAPD were prolonged. As soon as reperfusion began, MAPA and Vmax restored toward normal. The above result showed that MAP was not only a sensitive index for ischemia and reperfusion, but also a new study method on occlusion and reperfusion arrhythmias.

摘要:低氧下的通气抑制是机体在低氧条件下通气习服中的抑制性因素作用的表现,其机理与中枢内某些抑制性递质的活动有关,本实验用放射免疫测定法、高效液相-电化学测定法、(~3H)2-脱氧葡萄糖结合放射自显影方法、离体脑薄片胞外记录等手段,探讨β-内啡肽,单胺类神经递质对低氧通气抑制的影响,研究低氧通气抑制的中枢定位和通路,实验在去外周化学感受器传入神经、氨基甲酸乙酯麻醉的家兔上以及大鼠和人体上进行.低

摘要:为了进一步研究精子抗原及其相应抗体在不育中的作用,本文用SDS-PAGE和免疫印迹法检查了一对长期不育夫妇之间的抗精子免疫应答.该夫妇双方均含高滴度抗精子抗体.丈夫精子膜蛋白提取液中分子量84KD蛋白含量显著增加,为正常男性的3～5倍.该成分在免疫印迹中可被夫妇双方血清特异性识别.提示不育男性精子

摘要:立体定向技术截今已有80年历史,但真正应用到临床只有40年.传统的定向手术,主要是用于精神外科和功能性神经外科的治疗.由于疼痛的“闸门学说”以及左旋多巴的问世,使风弥一时的定向手术转入低谷.七十年代后,CT的广泛应用,引起定向技术的革命性进展.1976年,Rergstrom和Greitz首先报告利用CT定位获得成功.继之,文

摘要:变性(denaturation)是蛋白质和核酸等生物大分子的重要特性,也是研究它们的结构与功能的常用手段.我国生物化学家吴宪(1931)首先提出了蛋白质的变性理论,其后有许多作者对蛋白质的变性进行了广泛深入的研究.目前,有关蛋白质变性的概念都强调三点内容①具有物理或化学的变性因素;②蛋白质(包括核酸)分子在进行变

摘要:在举国上下学习、贯彻我国国民经济和社会发展十年规划和八五计划的第一年,在1991年的金秋时节,泸州医学院迈着奋进的步代,跨入了不惑之年.在这举校欢庆的时刻,我代表学院党委向为泸医的建设、发展呕心沥血,付出艰辛劳动,做出宝贵贡献的老领导、老同志、全院师生员工致以崇高的敬意和亲切的慰问,向全体校友和一切关心、支持泸医发展的朋友们、同志们表示衷心的感谢和诚挚的问候!我院前身是西南区川南医士学

摘要:本文对10周肥胖小鼠的血糖、血胰岛素浓度和棕色脂肪组织的乙酰辅酶A羧化酶(ACC)活性进行了研究.10周金硫葡萄糖(GTG)小鼠呈现高血糖,高胰岛素血症,其棕色脂肪组织用u/g鲜组织表示的ACC活性均低于对照,而用mu/mg蛋白质表示时,三组动物的总ACC活性与对照无明显差异.基础和柠檬酸盐刺激的ACC活性则低于对照.结果表明,10周GTG肥胖鼠棕色脂肪组织存在胰岛素抵抗.

摘要:研究了30只麻醉、肌肉松驰和人工通气家兔颈迷走神经切断前后急性窒息时膈神经放电反应的差异.切断迷走神经后窒息潜伏期延长,兴奋期、抑制期和耐受窒息时间缩短(P<0.01).积分膈神经放电幅度兴奋期和抑制期明显降低(P<0.01).兴奋期频率增值显著减少(P<0.01).恢复胡出现中枢呼吸活动时间延长.这些差别与动脉血气变化,切断喉上神经、喉返神经和腹迷走神经无关(P>0.05).提示肺迷走神经紧张性传入能加剧窒息膈神经放电反应.

摘要:In this study the effect of electric stimulus at auricular visceral points on the rabbit's myoelectric activity of sphincter of oddi(SO)under three conditions(normal,celiac vagal trunk sectioned and M-receptor blocked)was observed. A needle electrode was poisitioned in SO to record myoelectric activity. The electric stimulus frequency 10 hertz, intensity 4～6 volts and time 10 minutes. In 14 animals the change of myoelectric activity of SO responding to auricular point stimulus was recorded before and after vagotomy, respectively. Results: under normal condition(vagus not amputated)after stimulus the SO myoelectric activity rate decreased from the control level 7.17±1.84 spike bursts/min(SB/min)to 4.76±1.68 SB/min(p<0.01),but in vagotomy background after stimulus the SO myoelectric activity rate slightly decreased from 4.14±1.57 SB/min to 3.36±1.60 SB/min.(p>0.05).In another 15 animals atropine(0.2mg/kg)was administrated intravenously to block M-receptor. In Vagotomy group auricular point stimulus caused SO myoelectric activity rate to fall from the control level 8.19±1.29 SB/min to 4.71±1.29 SB/min(p<0.01).On the condition of M-receptor blocked the rate altered from 4.15±1.10 SB/min to 4.25±0.92 SB/min(p>0.05).All these results indicate:①Electric stimulus of auricular visceral points has

摘要:本文论述三焦主持水道、司理气机两大功能.水道不利则真水不行常道变为水邪.气机郁遏则相火不得泄越,化为郁火,从而导致百病丛生.且与肺、脾、肾和肝胆的关系极为密切.笔者多年来根据上述认识对“久咳不已”、“小儿遗尿”、“习惯性便秘”、“功能性水肿”、“地方性氟骨症”等疑难病证,从三焦辨治均获良效.本文对其病机、治法和方药结合病案作了探讨,将对指导临床有一定意义.

摘要:本文报告了25例结缔组织疾病患者的性及生殖功能与29例健康人对照观察结果,调查内容包括:婚龄、病程、怀孕及生产胎次、自然流产胎数、月经初潮时间,病后行经情况、服用药物及时间、性功能情况、性高潮出现、性欲要求、每月性交次数、男性病人有无阳萎早泄等.调查结果提出:20例女性结缔组织疾病患者月经

摘要:本文观察针灸足三里穴对人体红细胞免疫功能及T淋巴细胞脂酶活性的影响.结果表明连续三天灸、针、温针双足三里后,除灸组RBC-IC、T淋巴细胞酯酶活性无明显增强外,针、温针组均能增强RBC-C_3b受体免疫粘附活性和提高红细胞C_3b受体结合循环免疫复合物的能力,亦可同时促进体外周血中T淋巴细胞酯酶的活性.

摘要:本文对我国胃癌高、低发区64个病理科1541例进展期胃癌(AGC)的临床和病理特点进行了研究,结果表明:①高发区AGC1293例(83.8%),低发区248例(16.2%),患者多为老年,男多于女,病程短,症状多不典型,常以呕血、便血急诊入院;②肉眼,癌多累及胃窦小弯,以溃疡和浸润型多见;镜下,癌溃疡底部坏死明显,瘢痕少,并常有肌残留和癌浸润;③部份癌细胞可显示形态和功能异质性现象;④研究证实本组癌旁胃粘膜伴发病变的检出率及其病变程度均明显高于和重于同例非癌旁同层病变(P<0.001),提示前者与胃癌的发生关系更密切.

摘要:In investigating the oxidation state of various metabolites the author discovered that if the concept of carbon oxidation number is modified slightly, it turns into a brand-new parameter of organic compounds: the carbon reduction number(CRN).CRN is defined as the number of electrons attracted towards a carbon when carbon in CO_2, in which all the 4 valence electrons have moved away from carbon, is taken as the starting point. CRN of a carbon compound is the number of electrons attracted towards the whole carbon skeleton, which can indicate the number of electrons that have been combined by a compound during its evolution from CO_2, or the number of electrons that will be released from it when oxidtion takes place. CRN is also a useful bioenergetic parameter for calculating the yield of ATP when fuel molecules are oxidized in organisms:

摘要:本文报告使用作者自行设计制造的,可供电子计算机体层摄(CT),核磁共振(MR)和普通X线摄片定位的JP型多功能立体向仪行CT立体定向脑深部手术52例.其中16例采用通用计算方法,由辅助性微机求出靶点;另36例配用CT适配器,用测量法直接在CT机上定出靶点坐标.80%以上的病灶位于丘脑基底平面以下.手术类型包括活检、囊肿吸除、血肿穿刺引流、内放射源注入以及配合开颅的定向激光小病灶切除.在含有诊断性目的手术的36例中,术后均获得确定性诊断,其中10例术前诊断困难或与术后病理诊断不相符合.术后死亡3例,轻偏瘫1例.文中对CT定向手术的作用、定位准确性、病例的选择、手术并发症以及手术的优缺点进行了讨论.

摘要:作者对我国地方性氟中毒防治工作标准(1981)提出导议,并运用TF诊断标准,对彭水县地氟病区出生的12周岁儿童作了实地调查分析.结果发现:①病区越重牙损越重;②氟牙检出率也越高;③每颗牙的损害程度亦越重.作者据调查结果,参照现行标准,提出病出划分的设想:①调查对象为当地出生的12-15岁儿童;②轻病区为氟牙患病

摘要:腹膜透析期间,净超滤量(Net Net UF)和腹腔淋巴回流量是决定腹透时液体转运的重要参数.近年来国外学者用各种药物来调控其变化规律,以达到提高净超滤、降低淋巴回流,提高透析效能的作用.本文用RISA作标记物,使用胆碱磷膀、新斯的明,内毒素加入透析液中.对Wistar大鼠腹透、探明其对NetUF和Lf的影响.结果未见有降低Lf增加NetuF的作用.选用有效而对人体无付作用的药物来改变腹适时液体转运规律,提高透析效能是今后值得进一步研究的方向.

摘要:Adult learning a second language presents an important, huge task at present. A lot of factors are involved in it. The paper concerns the relevant aspects, e. g. physical, psychological, sociological, cognitive, linguistic ones, and some preferable principles and approaches to the learning on the basis of the analysis of those factors.

摘要:本文报告15例复杂性静脉漏性阳萎患者,行双侧髂内静脉,阴茎根部至大隐静脉及股静脉的侧支和阴茎背深静脉结扎.疗效达93%.认为这种梯形分级断流手术较全面而系统地阻挡了阳茎静脉回流.有利于阴茎血液储存.改善勃起状态,还可预防远心端更多侧支循环建立,提高和巩固疗效.

摘要:本文报告28年间73例华枝睾吸虫胆道感染与结石的手术治疗经验.其中,非结石性胆管、胆囊炎占46.6%,结石性胆管、胆囊炎占53.4%.合并肝、胆、胰癌7例,占9.6%(随机对照组为0).手术治疗方式8种.住院病死率8.2%.手术并发症率47.9%.残留结石率48.7%.本文就华枝睾吸虫感染对肝胆系统的严重危害、与胆道蛔虫临床的比较、发病机理、外科疗效及改进进行了讨论.

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摘要:本文应用Franz接触电极导管,引导实验性急性心肌梗塞时犬心内膜的单相动作电位(MAP),动态观察其演变特点.结果显示,结扎LAD后,心内膜缺血区MAPA立即减小,Vmax降低,平台期出现抬高、缩短、消失的渐进变化过程,APD_(50)轻度缩短,APD_(50)则延长,这些变化随缺血时间而逐渐加重.非缺血区则无此变化.实验发现,同步记录的ECG改变不能反映缺血程度.缺血后10分钟内,心肌电活动处于极不稳定状态,易发生心律失常.上述结果表明MAP不失为一种反映心肌缺血损伤演变过程的敏感指标,为该导管技术在临床研究中的可行性提供了进一步的客观依据.

摘要:有效地控制人口增长,使用避孕药是其中重要措施之一.复方甲基炔诺酮乙片为一长效口服避孕药(以下简称长效复方18甲),避孕效果可靠,但不良反应甚多.在不影响其疗效的前提下,为减轻不良反应,使服药者乐于服用,作者采用家兔交配排卵法,观察长效复方18甲减量后的抗排卵作用.本实验将长效复方18甲人用临床剂量折算成家兔等效剂量,分为3个不同减量组、1个全量组和1个空白对照组,其中观察到3/4剂量组获得良好抗排卵效果,抗排卵率为80%,与全量组近似.

摘要:酸甘止痒合剂小鼠24小时内口服176g/kg(相当于临床用量的328倍),观察7天,无不良反应,无死亡.因已达最大药液浓度和最大胃纳量,故未测出LD_(50).大鼠口服33g/kg,连续给药60天(每日用量相当于临床用量72倍),对大鼠肝肾功能(SGPT及BUN值)和血象均无明显影响.各给药组用药前后体重比较,均明显增加,且与对照组比较其增重的差别无显著性,说明该制剂对大鼠的生长发育无抑制作用.解剖肉眼观察及镜检,大鼠心、肝、肾组织形态未见特殊改变.停药两周后重复上述各项检查无异常发现.该制剂对组胺所致的豚鼠局部皮肤反应和组胺所致的家兔肠平滑肌收缩反应均有明显抑制作用.对小鼠腹腔巨噬细胞的吞噬功能和胸腺、脾脏的增长亦有明显抑制作用.

摘要:通过微机对112例健康成人记录Langner倡导的三个最大肢导联和V_4-V_6导联的高频心电图.对两个不同年龄组(40岁为界)的切迹、最高频率以及频谱含量进行分析,结果表明:①正常成人六导联组合切迹数总和不超过3个,超过3个切迹的假阳性率的12.54%,两年龄组间无显著性差异(P>0.05).②低龄组最高频率较高龄组高,年龄组间显著性检验(P<0.05).③年龄与最高频率呈负相关,显著性检验有高度显著性(P<0.01);年龄与切迹数相关较离散0.020.05).④谱图分析表明,两年龄组的功率百分比在20HZ内最高,随频段增多,功率百分比下降,50HZ以后接近最低;两年龄组在30HZ内频谱含量无明显差异,30HZ以后高龄组频谱含量较低龄组增多.

摘要:对比观察电针耳尖穴对积分膈神经放电的影响.经22只家兔105次电针发现:在自然呼吸放电频率增加2.41±1.24次/10秒,放电幅度增大3.55±2.03mm(P<0.001);窒息兴后期频率增加2.16±1.22次/10秒,幅度增吕2.69±1.36mm(P<0.001);抑制期频率增加2.07±1.07次/10秒.幅度增大2.12±2.00mm(P<0.005).上述三种状态下电针作用最长维持时间依次为26分、330秒和280秒.结果表明:电针耳尖穴有显著增加膈神经放电频率和幅度的作用,但随窒息加重有逐渐减弱的现象.提示电针耳尖穴改善呼吸状况,应早期刺激为好.

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摘要:养肝止痛口服液是根据临床痛证用药需要,以当归,白芍、川芎等中药组方,采用渗漉、蒸馏等法制备的口服液制剂,具有养肝止痛功能.临床用于多种痛证均收到满意疗效.制、制研究表明:该品处方设计、剂型选择、制备工艺合理,制剂质量稳定,卫生学指标符合规定,具有一定科学性、合理性及可行性.

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摘要:本文报告胆石并肝胆管炎58例并分析其临床意义.发现:仅基于出现夏柯氏/雷诺氏征诊断肝内胆管炎是不妥当的,因为肝内胆管结石者较之肝外胆石有更不典型的临床表现及更复杂的病理特征.提出建立合理的诊断应基于:胆道梗阻背景,右上腹隐钝痛,寒颤发热,肝不对称肿大,早期出现内毒素血症.

摘要:本文总结我院对茎突综合征近10年的临床研究,发现其发生率占耳鼻咽喉科门诊病员的0.3%;正常成人茎突X线测量平均长度为右侧30.33mm、左侧31.88mm;在117例咽异感症中,本病的检出率为50.4%;在504侧咽部扪诊中阳性率达87.1%;随访半年以上的经口内和颈外途径茎突切短术后的有效率分别为68.75%及80%,且效果较稳定;非手术的综合疗法较单一疗法效果好(P<0.05).文中对扪诊手法、诊断标准、手术技巧及保守疗法等,进行了一些探索和讨论.

摘要:应用国产简易动态心电图(DCG)仪检查冠心病109例、心肌炎55例和其他心血管病60例.检出各种心律失常421例次和S-T段压低88例,同期心电图分别只检出31例次和20例,两者均有显著差异性(P<0.01),对DCG中发现的心律失常、心率变化和S-T段变化,结合病情进行动态分析,并讨论心律失常尤其是过早搏动的临床价值和S-T段改变的机理,证实简易DCG仪能实现DCG基本功能,具有推广应用价值.

摘要:本文观察了11例甲亢合并糖尿病、15例单纯性甲亢和15例单纯性糖尿病患者的甲状腺机能状态、口服葡萄糖耐量(OGTT)-胰岛素释放试验.发现单纯性甲亢患者糖耐量减低的发生率为46.6%.胰岛素分泌释放和IRI/BG比值呈高值;甲亢合并糖尿病患者OGTT-胰岛素释放和IRI/BG比值完全与单纯性糖尿病患者相同,胰岛有严重损害,储备能力下降,胰岛素释放呈延缓和低值.提示甲亢合并糖尿糖患者的甲亢和糖尿病是两个独立并存的疾病,两者无因果关系,但两者相互影响和加重,故应对二病并存及早识别和积极治疗.

摘要:本文报告151例闭合性脑外伤的脑地形图和脑电图检测的对比分析,两者结果符合数为127例(82.5%),不符合数27例(17.5%).异常率为55.2%和48.1%,两者具有显著差异.说明脑地形图有较高的诊断意义.本组有无昏迷史的异常率脑地形图或脑电图均差异不大.

摘要:本文报告了酚妥拉明联合多巴胺治疗重症肺心病20例.治疗方法为:酚妥拉明10mg加多巴胺20mg,以10%葡萄糖水稀释缓慢静摘,每日1-2次,2周为一疗程.治疗前后对比,血气分析有显著改善,与对照组比较P<0.02.治疗组总有效率为95%,与对照组比较有极显著差异(P<0.005).未发现有明显副作用.

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摘要:应用动态心电图(DCG)对193例心脏病患者进行24小时观察,比较了白天清醒与夜间睡眠期的窦性心律及各种心律失常的变化情况.结果表明:夜间睡眠期多数心脏病患者(冠心病、高心病、心肌炎等)的室性心律失常减轻;室上性心律失常加重,同时传导阻滞、窦性静止和逸搏数增多.

摘要:本文报告165例慢性阑尾炎的临床和病理分析结果,发现按国内概念诊断的慢性阑尾炎中,约70.3%的病例为急性或亚急性炎症表现.作者认为这类病例应归为复发性阑尾炎,并指出复发性或慢性阑尾炎宜手术治疗.

摘要:本文采用印Q和CES-D对45例SLE患者进行了配比病例对照研究.结果发现病例组E量表均分明显低于对照组(F=7.51,P<0.01),N量表均分高于对照组(F=6.71,P<0.05,抑郁均分高于对照组(T=1.87,P<0.05).这表明内倾型、不稳定型人格及抑郁可能是促进SLE的重要病理因素.

摘要:本文对70例再生障碍性贫血(再障)患者的15项细胞和体液免疫指标进行了观察.结果表明:LCAV、MC%、OKT_5、OKT_4/OKT_6、ERFC、血清免疫球蛋白(IgG、IgA、IgM)显著低于正常对照组,BLC%、OKT_8、血清C_3、CH_■、CIC显著高于对照组,OKT_4、LCBT与对照组无显著差异.对这些免疫指标的异常与再障及其分塑的关系进行了探讨.

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